Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.

Miao, Edward A; Alpuche-Aranda, Celia M; Dors, Monica; Clark, April E; Bader, Martin W; Miller, Samuel I; Aderem, Alan

Miao, Edward A; Alpuche-Aranda, Celia M; Dors, Monica; Clark, April E; Bader, Martin W; Miller, Samuel I; Aderem, Alan.

Affiliation

Miao EA; Institute for Systems Biology, Seattle, Washington 98103, USA.

Nat Immunol ; 7(6): 569-75, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16648853

Subject(s)

Apoptosis Regulatory Proteins/physiology; Calcium-Binding Proteins/physiology; Caspase 1/metabolism; Flagellin/immunology; Interleukin-1/metabolism; Salmonella Infections/immunology; Salmonella typhimurium/pathogenicity; Animals; Apoptosis Regulatory Proteins/genetics; Bacterial Proteins/genetics; Bacterial Proteins/immunology; Calcium-Binding Proteins/genetics; Cytoplasm/metabolism; Cytoplasm/microbiology; Enzyme Activation; Flagellin/genetics; Macrophages/enzymology; Macrophages/immunology; Macrophages/microbiology; Mice; Mice, Mutant Strains; Mutation; Protein Transport; Salmonella Infections/enzymology; Salmonella Infections/genetics; Salmonella typhimurium/genetics; Salmonella typhimurium/immunology; Toll-Like Receptor 5/genetics; Toll-Like Receptor 5/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Salmonella Infections / Salmonella typhimurium / Calcium-Binding Proteins / Interleukin-1 / Caspase 1 / Apoptosis Regulatory Proteins / Flagellin Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2006 Document type: Article Affiliation country: United States

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