The role of interface framework residues in determining antibody V(H)/V(L) interaction strength and antigen-binding affinity.

Masuda, Kenji; Sakamoto, Kenzo; Kojima, Miki; Aburatani, Takahide; Ueda, Takuya; Ueda, Hiroshi

Masuda, Kenji; Sakamoto, Kenzo; Kojima, Miki; Aburatani, Takahide; Ueda, Takuya; Ueda, Hiroshi.

Affiliation

Masuda K; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan.

FEBS J ; 273(10): 2184-94, 2006 May.

Article in En | MEDLINE | ID: mdl-16649995

Subject(s)

Antigens/metabolism; Binding Sites, Antibody; Immunoglobulin Light Chains/metabolism; Immunoglobulin Variable Region/physiology; Peptide Library; Amino Acid Sequence; Cells, Cultured; Immunoglobulin Light Chains/genetics; Immunoglobulin Variable Region/genetics; Molecular Sequence Data; Mutagenesis

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Collection: 01-internacional Database: MEDLINE Main subject: Binding Sites, Antibody / Immunoglobulin Variable Region / Immunoglobulin Light Chains / Peptide Library / Antigens Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2006 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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