Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse.

Zaher, Hani; Khan, Anis A; Palandra, Joe; Brayman, Timothy G; Yu, Linning; Ware, Joseph A

Zaher, Hani; Khan, Anis A; Palandra, Joe; Brayman, Timothy G; Yu, Linning; Ware, Joseph A.

Affiliation

Zaher H; Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. hani.zaher@pfizer.com

Mol Pharm ; 3(1): 55-61, 2006.

Article in En | MEDLINE | ID: mdl-16686369

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Absorption/drug effects; Quinazolines/pharmacology; Sulfasalazine/metabolism; Sulfasalazine/pharmacokinetics; ATP Binding Cassette Transporter, Subfamily B/genetics; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/drug effects; ATP-Binding Cassette Transporters/genetics; Administration, Oral; Animals; Area Under Curve; Biological Availability; Gefitinib; Injections, Intravenous; Male; Mice; Mice, Knockout; Sulfasalazine/administration & dosage; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Sulfasalazine / ATP-Binding Cassette Transporters / Absorption Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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