Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.

Anari, M Reza; Creighton, Mellissa D; Ngui, Jason S; Tschirret-Guth, Richard A; Teffera, Yohannes; Doss, George A; Tang, Wei; Yu, Nathan X; Ciccotto, Suzanne L; Hobra, Donald F; Coleman, John B; Vincent, Stella H; Evans, David C

Anari, M Reza; Creighton, Mellissa D; Ngui, Jason S; Tschirret-Guth, Richard A; Teffera, Yohannes; Doss, George A; Tang, Wei; Yu, Nathan X; Ciccotto, Suzanne L; Hobra, Donald F; Coleman, John B; Vincent, Stella H; Evans, David C.

Affiliation

Anari MR; Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, P.O. Box 4, PA 19486, USA. reza_anari@yahoo.com

Drug Metab Dispos ; 34(8): 1367-75, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16698892

Subject(s)

Azetidines/pharmacokinetics; Glutathione/metabolism; Receptors, Lysosphingolipid/agonists; Thiophenes/pharmacokinetics; Administration, Oral; Animals; Azetidines/administration & dosage; Azetidines/urine; Bile/chemistry; Biotransformation; Dogs; Feces/chemistry; Injections, Intravenous; Intestinal Mucosa/metabolism; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Thiophenes/administration & dosage; Thiophenes/urine

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Collection: 01-internacional Database: MEDLINE Main subject: Azetidines / Thiophenes / Receptors, Lysosphingolipid / Glutathione Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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