7-Bromoindirubin-3'-oxime induces caspase-independent cell death.

Ribas, J; Bettayeb, K; Ferandin, Y; Knockaert, M; Garrofé-Ochoa, X; Totzke, F; Schächtele, C; Mester, J; Polychronopoulos, P; Magiatis, P; Skaltsounis, A-L; Boix, J; Meijer, L

Ribas, J; Bettayeb, K; Ferandin, Y; Knockaert, M; Garrofé-Ochoa, X; Totzke, F; Schächtele, C; Mester, J; Polychronopoulos, P; Magiatis, P; Skaltsounis, A-L; Boix, J; Meijer, L.

Affiliation

Ribas J; CNRS, Cell Cycle Group and UPS2682, Station Biologique, Bretagne, France.

Oncogene ; 25(47): 6304-18, 2006 Oct 12.

Article in En | MEDLINE | ID: mdl-16702956

Subject(s)

Cell Death/drug effects; Cyclin-Dependent Kinases/antagonists & inhibitors; Indoles/pharmacology; Oximes/pharmacology; Protein Kinase Inhibitors/pharmacology; Amino Acid Chloromethyl Ketones/pharmacology; Animals; CDC2 Protein Kinase/antagonists & inhibitors; Caspases/physiology; Cell Cycle/drug effects; Cell Line; Cell Line, Tumor/drug effects; Cell Line, Tumor/enzymology; Cell Nucleus/ultrastructure; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Cysteine Proteinase Inhibitors/pharmacology; Female; Glycogen Synthase Kinase 3/antagonists & inhibitors; Humans; Indoles/chemical synthesis; Indoles/chemistry; Male; Mice; Oximes/chemical synthesis; Oximes/chemistry; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2/physiology; Quinolines/pharmacology; Recombinant Fusion Proteins/antagonists & inhibitors; STAT3 Transcription Factor/metabolism; Spodoptera; Starfish; Structure-Activity Relationship; Swine; Tumor Suppressor Protein p53/physiology; bcl-X Protein/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Cell Death / Cyclin-Dependent Kinases / Protein Kinase Inhibitors / Indoles Type of study: Prognostic_studies Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2006 Document type: Article Affiliation country: France Country of publication: United kingdom

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