Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor. | J Org Chem;71(11): 4320-3, 2006 May 26. | MEDLINE

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Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor.

Roy, Amélie; Gosselin, Francis; O'Shea, Paul D; Chen, Cheng-y.

Affiliation

Roy A; Department of Process Research, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Québec H9H 3L1, Canada. amelie_roy@merck.com

J Org Chem ; 71(11): 4320-3, 2006 May 26.

Article in En | MEDLINE | ID: mdl-16709080

Subject(s)

Cathepsins/antagonists & inhibitors; Imines/chemistry; Lithium/chemistry; Cathepsin K; Molecular Structure

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Collection: 01-internacional Database: MEDLINE Main subject: Cathepsins / Imines / Lithium Language: En Journal: J Org Chem Year: 2006 Document type: Article Affiliation country: Canada Country of publication: United States

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Collection: 01-internacional Database: MEDLINE Main subject: Cathepsins / Imines / Lithium Language: En Journal: J Org Chem Year: 2006 Document type: Article Affiliation country: Canada Country of publication: United States