TCR gamma delta intraepithelial lymphocytes are required for self-tolerance.

Locke, Natasha R; Stankovic, Sanda; Funda, David P; Harrison, Leonard C

Locke, Natasha R; Stankovic, Sanda; Funda, David P; Harrison, Leonard C.

Affiliation

Locke NR; Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.

J Immunol ; 176(11): 6553-9, 2006 Jun 01.

Article in En | MEDLINE | ID: mdl-16709812

Subject(s)

Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Receptors, Antigen, T-Cell, gamma-delta/physiology; Self Tolerance; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; Animals; Animals, Newborn; CD8 Antigens/physiology; Diabetes Mellitus, Type 1/epidemiology; Diabetes Mellitus, Type 1/immunology; Diabetes Mellitus, Type 1/prevention & control; Female; Incidence; Insulin/administration & dosage; Intestinal Mucosa/pathology; Lymphocyte Activation/drug effects; Lymphopenia/immunology; Male; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, Transgenic; Receptors, Antigen, T-Cell, gamma-delta/biosynthesis; T-Lymphocyte Subsets/pathology; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/transplantation; Thymectomy

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocyte Subsets / Receptors, Antigen, T-Cell, gamma-delta / Self Tolerance / Intestinal Mucosa Type of study: Incidence_studies / Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2006 Document type: Article Affiliation country: Australia Country of publication: United States

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