A case of hypothyroid Graves' disease following external radiation therapy to the cervical region.
Endocr J
; 53(3): 357-61, 2006 Jun.
Article
in En
| MEDLINE
| ID: mdl-16714839
ABSTRACT
A case of hypothyroid Graves' disease occurred following external radiation therapy to the cervical region is described. Severe hypothyroidism developed in a 56-year-old man 6 months after external radiation therapy for submandibular cancer. Serological evaluation of thyroid autoimmunity revealed the presence of antithyroid antibodies and thyrotropin-binding inhibitory immunogloblins (TBII). Diplopia, limitation of downward gaze, and palpebral edema developed 2 years after levothyroxine replacement therapy. Ocular magnetic resonance imaging revealed marked hypertrophy of the bilateral extraocular muscles with signal hyperintensity on T2-weighted images. This infiltrative ophthalmopathy showed marked improvement after additional treatment with high-dose methylprednisolone and orbital radiation, in parallel with a decrease in TBII. These results suggest that radiation-associated thyroidal injury might be associated with the etiology of hypothyroid Graves' disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Injuries
/
Radiotherapy
/
Submandibular Gland Neoplasms
/
Graves Disease
/
Hypothyroidism
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Endocr J
Journal subject:
ENDOCRINOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Japan