CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis.

Teixeira-Clerc, Fatima; Julien, Boris; Grenard, Pascale; Tran Van Nhieu, Jeanne; Deveaux, Vanessa; Li, Liying; Serriere-Lanneau, Valérie; Ledent, Catherine; Mallat, Ariane; Lotersztajn, Sophie

Teixeira-Clerc, Fatima; Julien, Boris; Grenard, Pascale; Tran Van Nhieu, Jeanne; Deveaux, Vanessa; Li, Liying; Serriere-Lanneau, Valérie; Ledent, Catherine; Mallat, Ariane; Lotersztajn, Sophie.

Affiliation

Teixeira-Clerc F; INSERM, Unité 581, Hôpital Henri Mondor Créteil, F-9400 France.

Nat Med ; 12(6): 671-6, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16715087

Subject(s)

Liver Cirrhosis/pathology; Receptor, Cannabinoid, CB1/antagonists & inhibitors; Receptor, Cannabinoid, CB1/metabolism; Animals; Cannabinoid Receptor Modulators/metabolism; Disease Progression; Female; Humans; Liver/metabolism; Liver/pathology; Liver Cirrhosis/therapy; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines/metabolism; Piperidines/therapeutic use; Pyrazoles/metabolism; Pyrazoles/therapeutic use; Receptor, Cannabinoid, CB1/genetics; Receptor, Cannabinoid, CB2/metabolism; Retrospective Studies; Rimonabant; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta1

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Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Cannabinoid, CB1 / Liver Cirrhosis Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2006 Document type: Article

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