Bilateral osteonecrosis of the head of the femur during treatment with retinoic acid in a young patient with acute promyelocytic leukemia.
Int J Hematol
; 83(3): 252-3, 2006 Apr.
Article
in En
| MEDLINE
| ID: mdl-16720557
ABSTRACT
All-trans retinoic acid (ATRA) is the drug of choice for the treatment of acute promyelocytic leukemia (APL). In general, ATRA is well tolerated, but it does have side effects, the most severe of which is ATRA syndrome. We report the case of a young patient with APL treated with ATRA for induction and maintenance therapy who then developed avascular necrosis of both femoral heads. We also review cases of APL patients with osteonecrosis of the femoral head after ATRA therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tretinoin
/
Leukemia, Promyelocytic, Acute
/
Femur Head Necrosis
/
Antineoplastic Agents
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Int J Hematol
Journal subject:
HEMATOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Japan