Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.

Bergeron, Raynald; Yao, Jun; Woods, John W; Zycband, Emanuel I; Liu, Cherrie; Li, Zhihua; Adams, Alan; Berger, Joel P; Zhang, Bei B; Moller, David E; Doebber, Thomas W

Bergeron, Raynald; Yao, Jun; Woods, John W; Zycband, Emanuel I; Liu, Cherrie; Li, Zhihua; Adams, Alan; Berger, Joel P; Zhang, Bei B; Moller, David E; Doebber, Thomas W.

Affiliation

Bergeron R; Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey 07065, USA. raynald.bergeron@umontreal.com

Endocrinology ; 147(9): 4252-62, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16728496

Subject(s)

Diabetes Mellitus, Type 2/prevention & control; PPAR alpha/agonists; PPAR gamma/agonists; Animals; Blood Glucose/metabolism; Body Weight/drug effects; Eating/drug effects; Fasting; Food; Glucose Clamp Technique; Glucose Tolerance Test; Homeostasis; Hyperglycemia/prevention & control; Insulin/blood; Insulin/pharmacology; Islets of Langerhans/pathology; Male; Muscle, Skeletal/chemistry; PPAR alpha/pharmacology; Rats; Rats, Zucker; Triglycerides/analysis

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Collection: 01-internacional Database: MEDLINE Main subject: PPAR alpha / PPAR gamma / Diabetes Mellitus, Type 2 Limits: Animals Language: En Journal: Endocrinology Year: 2006 Document type: Article Affiliation country: United States

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