Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.

Ji, Zhiqin; Ahmed, Asma A; Albert, Daniel H; Bouska, Jennifer J; Bousquet, Peter F; Cunha, George A; Glaser, Keith B; Guo, Jun; Li, Junling; Marcotte, Patrick A; Moskey, Maria D; Pease, Lori J; Stewart, Kent D; Yates, Melinda; Davidsen, Steven K; Michaelides, Michael R

Ji, Zhiqin; Ahmed, Asma A; Albert, Daniel H; Bouska, Jennifer J; Bousquet, Peter F; Cunha, George A; Glaser, Keith B; Guo, Jun; Li, Junling; Marcotte, Patrick A; Moskey, Maria D; Pease, Lori J; Stewart, Kent D; Yates, Melinda; Davidsen, Steven K; Michaelides, Michael R.

Affiliation

Ji Z; Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6100, USA. zhiqin.ji@abbott.com

Bioorg Med Chem Lett ; 16(16): 4326-30, 2006 Aug 15.

Article in En | MEDLINE | ID: mdl-16735117

Subject(s)

Enzyme Inhibitors/pharmacology; Pyrimidines/chemistry; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Administration, Oral; Animals; Enzyme Inhibitors/chemistry; Humans; Inhibitory Concentration 50; Kinetics; Mice; Models, Chemical; Models, Molecular; Proto-Oncogene Proteins c-kit/metabolism; Pyrimidines/pharmacology; Receptor Protein-Tyrosine Kinases/chemistry; Receptor, TIE-2/metabolism; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-1/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Receptor Protein-Tyrosine Kinases / Enzyme Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom

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