Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival.

Song, Lanxi; Morris, Mark; Bagui, Tapan; Lee, Francis Y; Jove, Richard; Haura, Eric B

Song, Lanxi; Morris, Mark; Bagui, Tapan; Lee, Francis Y; Jove, Richard; Haura, Eric B.

Affiliation

Song L; Thoracic Oncology and Experimental Therapeutics and Molecular Oncology Programs, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA.

Cancer Res ; 66(11): 5542-8, 2006 Jun 01.

Article in En | MEDLINE | ID: mdl-16740687

Subject(s)

Apoptosis/drug effects; Carcinoma, Non-Small-Cell Lung/drug therapy; ErbB Receptors/metabolism; Lung Neoplasms/drug therapy; Protein Kinase Inhibitors/pharmacology; Pyrimidines/pharmacology; Thiazoles/pharmacology; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Cell Line, Tumor; Dasatinib; ErbB Receptors/genetics; Gene Deletion; Humans; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; Signal Transduction; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Thiazoles / Apoptosis / Carcinoma, Non-Small-Cell Lung / Protein Kinase Inhibitors / ErbB Receptors / Lung Neoplasms Limits: Humans Language: En Journal: Cancer Res Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links