Hypoxia converts human macrophages into triglyceride-loaded foam cells.

Boström, Pontus; Magnusson, Björn; Svensson, Per-Arne; Wiklund, Olov; Borén, Jan; Carlsson, Lena M S; Ståhlman, Marcus; Olofsson, Sven-Olof; Hultén, Lillemor Mattsson

Boström, Pontus; Magnusson, Björn; Svensson, Per-Arne; Wiklund, Olov; Borén, Jan; Carlsson, Lena M S; Ståhlman, Marcus; Olofsson, Sven-Olof; Hultén, Lillemor Mattsson.

Affiliation

Boström P; Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg, Sweden.

Arterioscler Thromb Vasc Biol ; 26(8): 1871-6, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16741148

Subject(s)

Foam Cells/metabolism; Foam Cells/pathology; Hypoxia/metabolism; Hypoxia/pathology; Lipid Metabolism; Macrophages/metabolism; Triglycerides/metabolism; Acyl-CoA Dehydrogenase/antagonists & inhibitors; Cells, Cultured; Coenzyme A Ligases/antagonists & inhibitors; Cytosol/metabolism; Humans; Immunoblotting; Lipid Metabolism/drug effects; Lipoproteins, LDL/pharmacology; Macrophages/pathology; Membrane Proteins/genetics; Membrane Proteins/metabolism; Perilipin-2; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Stearoyl-CoA Desaturase/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Triglycerides / Lipid Metabolism / Foam Cells / Macrophages / Hypoxia Limits: Humans Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2006 Document type: Article Affiliation country: Sweden Country of publication: United States

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