Low-molecular weight heparin induces in vitro trophoblast invasiveness: role of matrix metalloproteinases and tissue inhibitors.

Di Simone, N; Di Nicuolo, F; Sanguinetti, M; Ferrazzani, S; D'Alessio, M C; Castellani, R; Bompiani, A; Caruso, A

Di Simone, N; Di Nicuolo, F; Sanguinetti, M; Ferrazzani, S; D'Alessio, M C; Castellani, R; Bompiani, A; Caruso, A.

Affiliation

Di Simone N; Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy. nicoletta.disimone@virgilio.it

Placenta ; 28(4): 298-304, 2007 Apr.

Article in En | MEDLINE | ID: mdl-16750851

Subject(s)

Anticoagulants/pharmacology; Heparin, Low-Molecular-Weight/pharmacology; Trophoblasts/drug effects; Cell Movement/drug effects; Choriocarcinoma/drug therapy; Choriocarcinoma/enzymology; Choriocarcinoma/pathology; Dose-Response Relationship, Drug; Gene Expression; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Neoplasm Invasiveness; RNA, Messenger/metabolism; Tissue Inhibitor of Metalloproteinase-1/genetics; Tissue Inhibitor of Metalloproteinase-1/metabolism; Tissue Inhibitor of Metalloproteinase-2/genetics; Tissue Inhibitor of Metalloproteinase-2/metabolism; Trophoblasts/cytology; Trophoblasts/enzymology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Trophoblasts / Heparin, Low-Molecular-Weight / Anticoagulants Language: En Journal: Placenta Year: 2007 Document type: Article Affiliation country: Italy Country of publication: Netherlands

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