Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.

Shaw, Michael H; Freeman, Gordon J; Scott, Mark F; Fox, Barbara A; Bzik, David J; Belkaid, Yasmine; Yap, George S

Shaw, Michael H; Freeman, Gordon J; Scott, Mark F; Fox, Barbara A; Bzik, David J; Belkaid, Yasmine; Yap, George S.

Affiliation

Shaw MH; Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02906, USA.

J Immunol ; 176(12): 7263-71, 2006 Jun 15.

Article in En | MEDLINE | ID: mdl-16751369

Subject(s)

Down-Regulation/immunology; Interferon-gamma/physiology; Interleukin-10/physiology; Protein-Tyrosine Kinases/physiology; Th1 Cells/immunology; Th1 Cells/metabolism; Animals; Ascitic Fluid/immunology; CD4 Antigens/physiology; Cells, Cultured; Dose-Response Relationship, Immunologic; Down-Regulation/genetics; Genetic Predisposition to Disease; Immunity, Cellular/genetics; Interleukin-10/deficiency; Interleukin-10/genetics; Interleukin-10/metabolism; Interleukin-12/deficiency; Interleukin-12/genetics; Interleukin-12/physiology; Interleukin-12 Subunit p35; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Subunits/deficiency; Protein Subunits/genetics; Protein Subunits/physiology; Protein-Tyrosine Kinases/deficiency; Protein-Tyrosine Kinases/genetics; Signal Transduction/genetics; Signal Transduction/immunology; TYK2 Kinase; Th1 Cells/parasitology; Toxoplasma/immunology; Toxoplasma/pathogenicity; Toxoplasmosis/genetics; Toxoplasmosis/immunology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Down-Regulation / Interferon-gamma / Interleukin-10 / Th1 Cells Language: En Journal: J Immunol Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links