A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth.

Holmgren, Lars; Ambrosino, Elena; Birot, Olivier; Tullus, Carl; Veitonmäki, Niina; Levchenko, Tetyana; Carlson, Lena-Maria; Musiani, Piero; Iezzi, Manuela; Curcio, Claudia; Forni, Guido; Cavallo, Federica; Kiessling, Rolf

Holmgren, Lars; Ambrosino, Elena; Birot, Olivier; Tullus, Carl; Veitonmäki, Niina; Levchenko, Tetyana; Carlson, Lena-Maria; Musiani, Piero; Iezzi, Manuela; Curcio, Claudia; Forni, Guido; Cavallo, Federica; Kiessling, Rolf.

Affiliation

Holmgren L; Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, SE171 76 Stockholm, Sweden.

Proc Natl Acad Sci U S A ; 103(24): 9208-13, 2006 Jun 13.

Article in En | MEDLINE | ID: mdl-16754857

Subject(s)

Intercellular Signaling Peptides and Proteins/immunology; Membrane Proteins/immunology; Neoplasms/pathology; Neovascularization, Pathologic; Vaccines, DNA; Angiomotins; Animals; Antibodies/metabolism; Cell Line; Cell Movement/physiology; Endothelial Cells/cytology; Endothelial Cells/metabolism; Humans; Intercellular Signaling Peptides and Proteins/genetics; Membrane Proteins/genetics; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microfilament Proteins; Neoplasms/metabolism; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines, DNA / Intercellular Signaling Peptides and Proteins / Membrane Proteins / Neoplasms / Neovascularization, Pathologic Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Document type: Article Affiliation country: Sweden

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