The expression of a motoneuron-specific serine protease, motopsin (PRSS12), after facial nerve axotomy in mice.
J Plast Reconstr Aesthet Surg
; 59(4): 393-7, 2006.
Article
in En
| MEDLINE
| ID: mdl-16756256
ABSTRACT
Motopsin (PRSS12) is a mosaic serine protease that is preferentially expressed in motor neurons. To study the relationship between motopsin and motoneuron function, we investigated the expression of motopsin mRNA in facial nerve nuclei after facial nerve axotomy at the anterior margin of the parotid gland in mice. Neuronal function was monitored by assessing vibrissal motion in 3 months. Vibrissal behaviour on the injured side disappeared until the day 14 post-operation, and then recovered between the day 21 and 35. Motopsin expression decreased at the day 14, but markedly recovered by the day 21. In contrast, expression of growth-associated protein-43 (GAP-43) was induced at the day 3. These results suggest that the recovery of motopsin expression is correlated with the recovery of the facial motor neuronal function.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Serine Endopeptidases
/
Facial Nerve
/
Motor Neurons
Limits:
Animals
Language:
En
Journal:
J Plast Reconstr Aesthet Surg
Year:
2006
Document type:
Article
Affiliation country:
Japan