Brugada electrocardiographic pattern due to tricyclic antidepressant overdose.
J Electrocardiol
; 39(3): 336-9, 2006 Jul.
Article
in En
| MEDLINE
| ID: mdl-16777522
ABSTRACT
The Brugada syndrome is an arrhythmogenic disease with characteristic coved ST-segment elevation 2 mm or greater in the right precordial leads (type 1 Brugada electrocardiogram [ECG] pattern or "Brugada sign"] and is estimated to be responsible for at least 20% of sudden deaths in patients with structurally normal hearts [Circulation 2005;111(5)659-70]. The Brugada sign has been described in asymptomatic patients after exposure to various drugs. As published reports of the drug-induced Brugada sign have become increasingly prevalent, there is growing interest in the mechanisms responsible for this acquired ECG pattern and its clinical significance. We report a case of a patient who developed the type 1 Brugada ECG pattern after intentional overdose of a tricyclic antidepressant agent, review the literature concerning tricyclic antidepressant agent-induced Brugada sign, discuss potential mechanisms, and evaluate the clinical significance of this ECG abnormality.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ventricular Fibrillation
/
Bundle-Branch Block
/
Clonazepam
/
Desipramine
/
Electrocardiography
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
J Electrocardiol
Year:
2006
Document type:
Article
Affiliation country:
United States