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Homocysteine measurements in geriatric patients.
Raeder, S; Landaas, S; Laake, K; Lyberg, T; Engedal, K.
Affiliation
  • Raeder S; Department of Geriatric Medicine, Ullevaal University Hospital, Oslo, Norway.
Scand J Clin Lab Invest ; 66(4): 309-15, 2006.
Article in En | MEDLINE | ID: mdl-16777759
OBJECTIVE: Homocysteine measurements may be relevant in geriatric medicine as homocysteine has been identified as an independent risk factor for prevalent disorders such as occlusive arterial vascular disease, cognitive impairment and dementia. The aim of the present study was to study diagnostic correlates of plasma total homocysteine (tHcy) in geriatric in-patients. MATERIAL AND METHODS: Blood samples for the analysis of tHcy and related factors like serum vitamin B12, serum folate, red blood cell folate and clinical data were collected from geriatric patients (n=114) in stable clinical condition. RESULTS: Almost 40% of the patients had tHcy values above 20 micromol/L. tHcy correlated significantly with serum folate, serum vitamin B12, serum creatinine and congestive heart failure, but not with red blood cell folate, cerebrovascular disease, coronary heart disease or cognitive impairment. CONCLUSIONS: Hyperhomocysteinaemia seems to be frequent in geriatric patients and might primarily be an indicator of low folate and high creatinine values.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Hyperhomocysteinemia / Homocysteine Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Scand J Clin Lab Invest Year: 2006 Document type: Article Affiliation country: Norway Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Hyperhomocysteinemia / Homocysteine Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Scand J Clin Lab Invest Year: 2006 Document type: Article Affiliation country: Norway Country of publication: United kingdom