Sustained release formulation of erythropoietin using hyaluronic acid hydrogels crosslinked by Michael addition.

Hahn, Sei Kwang; Oh, Eun Ju; Miyamoto, Hajime; Shimobouji, Tsuyoshi

Hahn, Sei Kwang; Oh, Eun Ju; Miyamoto, Hajime; Shimobouji, Tsuyoshi.

Affiliation

Hahn SK; Department of Advanced Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang 790-784, Republic of Korea. skhanb@postech.ac.kr

Int J Pharm ; 322(1-2): 44-51, 2006 Sep 28.

Article in En | MEDLINE | ID: mdl-16781096

Subject(s)

Erythropoietin/chemistry; Hyaluronic Acid/chemistry; Hydrogels/chemical synthesis; Animals; Cross-Linking Reagents/chemistry; Delayed-Action Preparations; Dithiothreitol/chemistry; Drug Carriers; Erythropoietin/blood; Erythropoietin/pharmacokinetics; Hyaluronic Acid/pharmacokinetics; Hydrogels/chemistry; Hydrogels/pharmacokinetics; Methacrylates/chemistry; Peptides/chemistry; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Erythropoietin / Hydrogels / Hyaluronic Acid Limits: Animals Language: En Journal: Int J Pharm Year: 2006 Document type: Article Country of publication: Netherlands

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