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The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment.
Sawakami, Kimihiko; Robling, Alexander G; Ai, Minrong; Pitner, Nathaniel D; Liu, Dawei; Warden, Stuart J; Li, Jiliang; Maye, Peter; Rowe, David W; Duncan, Randall L; Warman, Matthew L; Turner, Charles H.
Affiliation
  • Sawakami K; Department of Orthopedic Surgery, Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, USA.
J Biol Chem ; 281(33): 23698-711, 2006 Aug 18.
Article in En | MEDLINE | ID: mdl-16790443
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Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Osteogenesis / Parathyroid Hormone / Peptide Fragments / Bone and Bones / LDL-Receptor Related Proteins / Mechanotransduction, Cellular / Wnt Proteins / Anabolic Agents Limits: Animals / Female / Humans / Male Language: En Journal: J Biol Chem Year: 2006 Document type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Osteogenesis / Parathyroid Hormone / Peptide Fragments / Bone and Bones / LDL-Receptor Related Proteins / Mechanotransduction, Cellular / Wnt Proteins / Anabolic Agents Limits: Animals / Female / Humans / Male Language: En Journal: J Biol Chem Year: 2006 Document type: Article Affiliation country: United States