Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.

Jeng, Jiiang-Huei; Wu, Hui-Lin; Lin, Bor-Ru; Lan, Wan-Hong; Chang, Hsiao-Hwa; Ho, Yuan-Soon; Lee, Po-Hsuen; Wang, Ying-Jan; Wang, Juo-Song; Chen, Yi-Jane; Chang, Mei-Chi

Jeng, Jiiang-Huei; Wu, Hui-Lin; Lin, Bor-Ru; Lan, Wan-Hong; Chang, Hsiao-Hwa; Ho, Yuan-Soon; Lee, Po-Hsuen; Wang, Ying-Jan; Wang, Juo-Song; Chen, Yi-Jane; Chang, Mei-Chi.

Affiliation

Jeng JH; Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.

Atherosclerosis ; 191(2): 250-8, 2007 Apr.

Article in En | MEDLINE | ID: mdl-16797553

Subject(s)

Alkaloids/pharmacology; Benzophenanthridines/pharmacology; Blood Platelets/drug effects; Calcium/metabolism; Cyclic AMP/metabolism; Cyclooxygenase Inhibitors/pharmacology; Isoquinolines/pharmacology; Platelet Aggregation Inhibitors/pharmacology; Platelet Aggregation/drug effects; Thromboxane B2/metabolism; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology; Adenylyl Cyclases/metabolism; Animals; Arachidonic Acid/pharmacology; Blood Platelets/metabolism; Collagen/pharmacology; Cyclooxygenase 1/metabolism; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; In Vitro Techniques; Rabbits; Receptors, Thromboxane/drug effects; Receptors, Thromboxane/metabolism; Thrombin/pharmacology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Thromboxane B2 / Blood Platelets / Platelet Aggregation Inhibitors / Platelet Aggregation / Calcium / Cyclooxygenase Inhibitors / Cyclic AMP / Alkaloids / Benzophenanthridines / Isoquinolines Limits: Animals Language: En Journal: Atherosclerosis Year: 2007 Document type: Article Affiliation country: Taiwan Country of publication: Ireland

Search on Google

Add to My VHL

XML

PubMed Links