The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.

Woolley, J L; Deangelis, D V; Crouch, R C; Shockcor, J P; Sigel, C W

Woolley, J L; Deangelis, D V; Crouch, R C; Shockcor, J P; Sigel, C W.

Affiliation

Woolley JL; Division of Pharmacokinetics and Drug Metabolism, Wellcome Research Laboratories, Research Triangle Park, NC 27709.

Drug Metab Dispos ; 19(3): 600-8, 1991.

Article in En | MEDLINE | ID: mdl-1680625

Subject(s)

Folic Acid Antagonists/pharmacokinetics; Pyrimidines/pharmacokinetics; Administration, Oral; Animals; Biological Availability; Biotransformation; Cell Survival/drug effects; Folic Acid Antagonists/administration & dosage; Folic Acid Antagonists/metabolism; Injections, Intravenous; Iodine Radioisotopes; Male; Pyrimidines/metabolism; Pyrimidines/pharmacology; Rats; Tetrahydrofolate Dehydrogenase/metabolism; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Folic Acid Antagonists Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1991 Document type: Article Country of publication: United States

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