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A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice.
Suh, Gee Young; Ham, Hyoung Suk; Lee, Shin-Hye; Choi, Jae Chul; Koh, Won-Jung; Kim, Soo-Youl; Lee, Jongmin; Han, Joungho; Kim, Hong Pyo; Choi, Augustine M K; Kwon, O Jung.
Affiliation
  • Suh GY; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Exp Lung Res ; 32(1-2): 43-53, 2006.
Article in En | MEDLINE | ID: mdl-16809220
ABSTRACT
Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.
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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Pneumonia / Transglutaminases / Lipopolysaccharides Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Lung Res Year: 2006 Document type: Article
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Pneumonia / Transglutaminases / Lipopolysaccharides Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Lung Res Year: 2006 Document type: Article