A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice.
Exp Lung Res
; 32(1-2): 43-53, 2006.
Article
in En
| MEDLINE
| ID: mdl-16809220
ABSTRACT
Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Pneumonia
/
Transglutaminases
/
Lipopolysaccharides
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Exp Lung Res
Year:
2006
Document type:
Article