Deficit in schizophrenia to recruit the striatum in implicit learning: a functional magnetic resonance imaging investigation.
Schizophr Res
; 87(1-3): 127-37, 2006 Oct.
Article
in En
| MEDLINE
| ID: mdl-16814986
In schizophrenia, explicit learning deficits have been well established although it is less clear whether these patients have deficits in implicit learning (IL). IL is thought to depend on intact striatal functioning. This study examined the hypothesis that schizophrenia patients show deficient recruitment of striatal activation during an IL paradigm, relative to performance-matched healthy comparison subjects. Ten subjects with schizophrenia on atypical antipsychotic medication and 10 age, gender, education, and performance matched healthy comparison subjects underwent fMRI while performing an IL task. On the basis of whole-brain and striatal region-of-interest analyses, we found a relative lack of striatal activation in schizophrenia patients. This result is consistent with convergent evidence of striatal dysfunction in schizophrenia.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Magnetic Resonance Imaging
/
Corpus Striatum
/
Learning
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Schizophr Res
Journal subject:
PSIQUIATRIA
Year:
2006
Document type:
Article
Affiliation country:
Canada
Country of publication:
Netherlands