The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

Celic, Ivana; Masumoto, Hiroshi; Griffith, Wendell P; Meluh, Pamela; Cotter, Robert J; Boeke, Jef D; Verreault, Alain

Celic, Ivana; Masumoto, Hiroshi; Griffith, Wendell P; Meluh, Pamela; Cotter, Robert J; Boeke, Jef D; Verreault, Alain.

Affiliation

Celic I; High Throughput Biology Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Curr Biol ; 16(13): 1280-9, 2006 Jul 11.

Article in En | MEDLINE | ID: mdl-16815704

Subject(s)

Histone Deacetylases/physiology; Histones/metabolism; Lysine/metabolism; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/enzymology; Acetylation; Amino Acid Sequence; Binding Sites; Cell Cycle/physiology; Cell Cycle Proteins/physiology; Chromatin/metabolism; DNA Damage; DNA Replication; Genome, Fungal; Genomic Instability; Histone Deacetylases/chemistry; Histone Deacetylases/genetics; Molecular Chaperones; Molecular Sequence Data; Mutation; Niacinamide/metabolism; Protein Processing, Post-Translational; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/genetics; Sequence Alignment; Sirtuins/chemistry; Sirtuins/genetics; Sirtuins/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Histones / Saccharomyces cerevisiae Proteins / Histone Deacetylases / Lysine Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom

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