Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors.

Bettio, Andrea; Honer, Michael; Müller, Cristina; Brühlmeier, Matthias; Müller, Ursina; Schibli, Roger; Groehn, Viola; Schubiger, August P; Ametamey, Simon M

Bettio, Andrea; Honer, Michael; Müller, Cristina; Brühlmeier, Matthias; Müller, Ursina; Schibli, Roger; Groehn, Viola; Schubiger, August P; Ametamey, Simon M.

Affiliation

Bettio A; Department of Chemistry and Applied Biosciences of ETH, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Zurich, Switzerland.

J Nucl Med ; 47(7): 1153-60, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16818950

Subject(s)

Carrier Proteins/biosynthesis; Fluorodeoxyglucose F18/pharmacology; Folic Acid/analogs & derivatives; Neoplasms/pathology; Positron-Emission Tomography/methods; Receptors, Cell Surface/biosynthesis; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Folate Receptors, GPI-Anchored; Folic Acid/metabolism; Humans; KB Cells; Mice; Mice, Nude; Models, Chemical; Neoplasms/metabolism; Protein Binding; Radiopharmaceuticals/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Receptors, Cell Surface / Fluorodeoxyglucose F18 / Positron-Emission Tomography / Folic Acid / Neoplasms Limits: Animals / Humans Language: En Journal: J Nucl Med Year: 2006 Document type: Article Affiliation country: Switzerland

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