Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

Cheng, Jie-Fei; Huang, Yujin; Penuliar, Richard; Nishimoto, Masahiro; Liu, Larry; Arrhenius, Thomas; Yang, Guang; O'leary, Eoin; Barbosa, Miguel; Barr, Rick; Dyck, Jason R B; Lopaschuk, Gary D; Nadzan, Alex M

Cheng, Jie-Fei; Huang, Yujin; Penuliar, Richard; Nishimoto, Masahiro; Liu, Larry; Arrhenius, Thomas; Yang, Guang; O'leary, Eoin; Barbosa, Miguel; Barr, Rick; Dyck, Jason R B; Lopaschuk, Gary D; Nadzan, Alex M.

Affiliation

Cheng JF; Department of Chemistry, Chugai Pharma USA, LLC., 6275 Nancy Ridge Drive, San Diego, California 92121, USA. jcheng@trlusa.com

J Med Chem ; 49(14): 4055-8, 2006 Jul 13.

Article in En | MEDLINE | ID: mdl-16821767

Subject(s)

Carboxy-Lyases/antagonists & inhibitors; Cardiotonic Agents/chemical synthesis; Isoxazoles/chemical synthesis; Administration, Oral; Animals; Biological Availability; Cardiotonic Agents/pharmacokinetics; Cardiotonic Agents/pharmacology; Crystallography, X-Ray; Isoxazoles/pharmacokinetics; Isoxazoles/pharmacology; Molecular Conformation; Myocardial Ischemia/drug therapy; Myocardial Ischemia/physiopathology; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Carboxy-Lyases / Cardiotonic Agents / Isoxazoles Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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