Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease.

Zeissig, S; Bürgel, N; Günzel, D; Richter, J; Mankertz, J; Wahnschaffe, U; Kroesen, A J; Zeitz, M; Fromm, M; Schulzke, J-D

Zeissig, S; Bürgel, N; Günzel, D; Richter, J; Mankertz, J; Wahnschaffe, U; Kroesen, A J; Zeitz, M; Fromm, M; Schulzke, J-D.

Affiliation

Zeissig S; Department of Gastroenterology, Charité, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.

Gut ; 56(1): 61-72, 2007 Jan.

Article in En | MEDLINE | ID: mdl-16822808

Subject(s)

Crohn Disease/metabolism; Membrane Proteins/analysis; Tight Junctions/metabolism; Adult; Aged; Cells, Cultured; Claudin-5; Claudins; Colitis, Ulcerative/metabolism; Colon, Sigmoid/metabolism; Cytokines/metabolism; Down-Regulation/physiology; Epithelium/metabolism; Humans; Intestinal Mucosa/metabolism; Male; Microscopy, Electron, Scanning/methods; Middle Aged; Occludin; Up-Regulation/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Tight Junctions / Membrane Proteins Limits: Adult / Aged / Humans / Male / Middle aged Language: En Journal: Gut Year: 2007 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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