The lipid peroxidation product 4-hydroxy-2,3-trans-1 nonenal decreases rat intestinal smooth muscle function in-vitro by alkylation of sulphydryl groups.

Van der Vliet, A; Van der Aar, E M; Bast, A

Van der Vliet, A; Van der Aar, E M; Bast, A.

Affiliation

Van der Vliet A; Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.

J Pharm Pharmacol ; 43(7): 515-7, 1991 Jul.

Article in En | MEDLINE | ID: mdl-1682468

Subject(s)

Aldehydes/pharmacology; Ethylmaleimide/pharmacology; Muscle, Smooth/drug effects; Alkylation; Animals; Drug Interactions; Intestine, Small/drug effects; Isoproterenol/pharmacology; Lipid Peroxidation; Male; Methacholine Chloride/pharmacology; Muscle Contraction/drug effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta/drug effects; Sulfhydryl Compounds/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Aldehydes / Ethylmaleimide / Muscle, Smooth Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 1991 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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