SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.

Friedmann, Elena; Hauben, Ehud; Maylandt, Kerstin; Schleeger, Simone; Vreugde, Sarah; Lichtenthaler, Stefan F; Kuhn, Peer-Hendrik; Stauffer, Daniela; Rovelli, Giorgio; Martoglio, Bruno

Friedmann, Elena; Hauben, Ehud; Maylandt, Kerstin; Schleeger, Simone; Vreugde, Sarah; Lichtenthaler, Stefan F; Kuhn, Peer-Hendrik; Stauffer, Daniela; Rovelli, Giorgio; Martoglio, Bruno.

Affiliation

Friedmann E; Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), ETH Hoenggerberg, 8092 Zurich, Switzerland.

Nat Cell Biol ; 8(8): 843-8, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16829952

Subject(s)

Aspartic Acid Endopeptidases/metabolism; Bacterial Proteins/metabolism; Dendritic Cells/drug effects; Interleukin-12/biosynthesis; Intracellular Membranes/drug effects; Tumor Necrosis Factor-alpha/metabolism; Animals; Aspartic Acid Endopeptidases/genetics; Bacterial Proteins/genetics; Blotting, Western; Cell Line; Cell Membrane/drug effects; Cell Membrane/metabolism; Cells, Cultured; Dendritic Cells/cytology; Dendritic Cells/metabolism; Endosomes/drug effects; Endosomes/metabolism; Flow Cytometry; HeLa Cells; Humans; Hydrolysis/drug effects; Intracellular Membranes/metabolism; Isoenzymes/genetics; Isoenzymes/metabolism; Microscopy, Fluorescence; RNA Interference

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Dendritic Cells / Aspartic Acid Endopeptidases / Tumor Necrosis Factor-alpha / Interleukin-12 / Intracellular Membranes Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2006 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom

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