Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

Haughton, Emma L; Tucker, Steven J; Marek, Carylyn J; Durward, Elaine; Leel, Val; Bascal, Zainab; Monaghan, Tanya; Koruth, Matthew; Collie-Duguid, Elaina; Mann, Derek A; Trim, Julie E; Wright, Matthew C

Haughton, Emma L; Tucker, Steven J; Marek, Carylyn J; Durward, Elaine; Leel, Val; Bascal, Zainab; Monaghan, Tanya; Koruth, Matthew; Collie-Duguid, Elaina; Mann, Derek A; Trim, Julie E; Wright, Matthew C.

Affiliation

Haughton EL; School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland.

Gastroenterology ; 131(1): 194-209, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16831602

Subject(s)

Carcinoma, Hepatocellular/pathology; Cell Differentiation/drug effects; Gene Expression Regulation, Neoplastic; Liver Neoplasms/pathology; RNA, Neoplasm/genetics; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Steroid/genetics; Rifampin/pharmacology; Blotting, Western; Carcinoma, Hepatocellular/drug therapy; Cell Proliferation/drug effects; Enzyme Inhibitors/therapeutic use; Hepatocytes/drug effects; Hepatocytes/pathology; Humans; In Vitro Techniques; Liver Neoplasms/drug therapy; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear/drug effects; Receptors, Steroid/drug effects; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / RNA, Neoplasm / Receptors, Steroid / Gene Expression Regulation, Neoplastic / Cell Differentiation / Receptors, Cytoplasmic and Nuclear / Carcinoma, Hepatocellular / Liver Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Gastroenterology Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United States

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