Neurodevelopmental outcomes in children with HIV infection under 3 years of age.
Dev Med Child Neurol
; 48(8): 677-82, 2006 Aug.
Article
in En
| MEDLINE
| ID: mdl-16836781
ABSTRACT
Following the introduction of combination antiretroviral therapy, children vertically infected with the human immunodeficiency virus (HIV-1) living in the developed world are surviving into adult life. This paper reviews the neurodevelopmental outcomes of 62 consecutively-presenting children with HIV-1 infection diagnosed before 3 years of age (32 males, 30 females; median age at presentation 6 mo). Neurological and developmental data are presented with immunological and virological responses to antiretroviral therapy. Fourteen children (22%) had abnormal neurological signs and 25 (40%) demonstrated significant developmental delay on standardized developmental assessments. Children presenting with more severe HIV-1 disease and immune compromise had significantly more abnormal neurological signs and developmental delays than children presenting with milder HIV-1 symptomatology. Immune function, control of HIV-1 viral replication, and growth parameters improved with antiretroviral therapy (median age at last follow-up 7 y 3 mo); however, abnormal neurological signs and significant gross motor difficulties persisted.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Developmental Disabilities
/
AIDS Dementia Complex
/
HIV-1
/
Anti-HIV Agents
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Dev Med Child Neurol
Year:
2006
Document type:
Article
Affiliation country:
United kingdom