5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.

Verheggen, Raphaela; Werner, Inga; Lücker, Anne; Brüss, Michael; Göthert, Manfred; Kaumann, Alberto J

Verheggen, Raphaela; Werner, Inga; Lücker, Anne; Brüss, Michael; Göthert, Manfred; Kaumann, Alberto J.

Affiliation

Verheggen R; Department of Neurosurgery, University of Göttingen, Göttingen, Germany.

Pharmacogenet Genomics ; 16(8): 601-7, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16847428

Subject(s)

Genetic Variation/physiology; Muscle Contraction/drug effects; Muscle Contraction/genetics; Receptor, Serotonin, 5-HT1B/metabolism; Receptor, Serotonin, 5-HT2A/metabolism; Serotonin/pharmacology; Temporal Arteries/drug effects; Temporal Arteries/metabolism; Adolescent; Adult; Aged; Aged, 80 and over; Female; Genotype; Heterozygote; Humans; Male; Middle Aged; Sumatriptan/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Temporal Arteries / Genetic Variation / Serotonin / Receptor, Serotonin, 5-HT1B / Receptor, Serotonin, 5-HT2A / Muscle Contraction Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Pharmacogenet Genomics Journal subject: FARMACOLOGIA / GENETICA MEDICA Year: 2006 Document type: Article Affiliation country: Germany Country of publication: United States

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