Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1.

Léonce, Stéphane; Kraus-Berthier, Laurence; Golsteyn, Roy M; David-Cordonnier, Marie-Hélène; Tardy, Christelle; Lansiaux, Amélie; Poindessous, Virginie; Larsen, Annette K; Pierré, Alain

Léonce, Stéphane; Kraus-Berthier, Laurence; Golsteyn, Roy M; David-Cordonnier, Marie-Hélène; Tardy, Christelle; Lansiaux, Amélie; Poindessous, Virginie; Larsen, Annette K; Pierré, Alain.

Affiliation

Léonce S; Institut de Recherches Servier, Cancer Drug Discovery, Croissy sur Seine, France. stephane.leonce@fr.netgrs.com

Cancer Res ; 66(14): 7203-10, 2006 Jul 15.

Article in En | MEDLINE | ID: mdl-16849567

Subject(s)

Acronine/analogs & derivatives; DNA Damage; DNA, Neoplasm/drug effects; ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis; Acronine/pharmacology; Alkylation; Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/genetics; Carcinoma, Squamous Cell/metabolism; Cell Cycle/drug effects; Checkpoint Kinase 2; DNA, Neoplasm/metabolism; Histones/metabolism; Humans; KB Cells; Phosphorylation; Protein Serine-Threonine Kinases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Acronine / DNA Damage / DNA, Neoplasm Limits: Humans Language: En Journal: Cancer Res Year: 2006 Document type: Article Affiliation country: France Country of publication: United States

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