Postnatal maturation of rat intestinal membrane: lipid composition and fluidity.
Comp Biochem Physiol A Comp Physiol
; 100(2): 301-7, 1991.
Article
in En
| MEDLINE
| ID: mdl-1685951
ABSTRACT
1. We studied the lipid composition and the fluidity of small intestine brush border membrane (BBM) of rats of different age 'very young' (5-7 weeks old), 'young' (9 weeks old), 'adult' (30 weeks old) and 'old' (85 weeks old). 2. Fluorescence anisotropy, as assessed by 1,6-diphenyl-1,3,5-hexatriene probe (DPH), was increased from very young to adult rats. 3. In agreement with these results the lipid composition in adult animals showed a lower lipid/protein ratio (derived mainly from a lower content of total polar lipids) and an increase of cholesterol esters and sphingomyelin (SM) saturation index. 4. A marked decrease of the order parameter was observed in the 'old' group, accompanied by a decreased cholesterol/phospholipid ratio. 5. The percentage distribution of membrane phospholipids significantly changed during development, but the modifications were not correlated with the anisotropy of DPH.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Jejunum
/
Membrane Lipids
Limits:
Animals
Language:
En
Journal:
Comp Biochem Physiol A Comp Physiol
Year:
1991
Document type:
Article
Affiliation country:
Italy