The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.

Ferreira, Alexander M; Isaacs, Harold; Hayflick, Joel S; Rogers, Kem A; Sandig, Martin

Ferreira, Alexander M; Isaacs, Harold; Hayflick, Joel S; Rogers, Kem A; Sandig, Martin.

Affiliation

Ferreira AM; Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada. aferreira@robarts.ca

Microcirculation ; 13(6): 439-56, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16864411

Subject(s)

CD18 Antigens/metabolism; Cell Movement/physiology; Integrin beta1/metabolism; Monocytes/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Adenine/analogs & derivatives; Adenine/pharmacology; Androstadienes/pharmacology; Cell Line; Cell Movement/drug effects; Chromones/pharmacology; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Humans; Integrin alpha4beta1/metabolism; Intercellular Adhesion Molecule-1/metabolism; Lymphocyte Function-Associated Antigen-1/metabolism; Monocytes/cytology; Morpholines/pharmacology; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors/pharmacology; Quinazolines/pharmacology; Signal Transduction/drug effects; Signal Transduction/physiology; Vascular Cell Adhesion Molecule-1/metabolism; Wortmannin; cdc42 GTP-Binding Protein/biosynthesis; rac1 GTP-Binding Protein/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Cell Movement / CD18 Antigens / Integrin beta1 / Phosphatidylinositol 3-Kinases Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Microcirculation Journal subject: ANGIOLOGIA Year: 2006 Document type: Article Affiliation country: Canada Country of publication: United States

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