Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection.
AIDS
; 20(12): 1591-5, 2006 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-16868439
ABSTRACT
OBJECTIVES:
This study examined the effects of HAART on neurocognitive functioning in persons with hepatitis C virus (HCV) and HIV co-infection.DESIGN:
A prospective study examining neurocognitive performance before and after HAART initiation.METHOD:
Participant groups included a mono-infected group (45 HIV+/HCV- participants) and a co-infected group (20 HIV+/HCV+ participants). A neuropsychological battery (attention/concentration, psychomotor speed, executive functioning, verbal memory, visual memory, fine motor, and gross motor functioning) was used to evaluate all participants. After 6 months of HAART, 31 HIV+ mono-infected and 13 HCV+/HIV+ co-infected participants were reevaluated.RESULTS:
Neurocognitive functioning by domain revealed significantly worse performance in the co-infected group when compared to the monoinfected group on domains of visual memory and fine motor functioning. Assessment of neurocognitive functioning after antiretroviral therapy revealed that the co-infected group was no longer performing worse than the monoinfected group.CONCLUSIONS:
The findings of the current study suggest that persons with HCV+/HIV+ co-infection may have greater neurocognitive declines than persons with HIV infection alone. HCV+/HIV+ co-infection may accelerate the progression of HIV related neurocognitive decline.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Hepatitis C
/
Antiretroviral Therapy, Highly Active
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2006
Document type:
Article
Affiliation country:
United States