Arugosins G and H: prenylated polyketides from the marine-derived fungus Emericellanidulans var. acristata.
J Nat Prod
; 69(7): 995-1000, 2006 Jul.
Article
in En
| MEDLINE
| ID: mdl-16872131
ABSTRACT
The fungus Emericella nidulans var. acristata was isolated as an endophyte from a Mediterranean green alga. Cultivation of this fungus yielded two new compounds, arugosins G (1) and H (2), together with the known metabolites 3-9. Arugosins (1-4) are benzophenone derivatives, biosynthetically related to the xanthones 5, 6, and 9. The indole alkaloid 7 displayed antitumor activity in a panel of 36 human tumor cell lines, exhibiting a mean IC(50) value of 5.5 microg/mL in an in vitro survival and proliferation assay. Furthermore, compounds 3 and 4 showed moderate antitumor activity toward individual tumor cell lines. None of compounds 1-8 exhibited any immunostimulatory activity assessed as the capacity to induce cytokines in PBMCs from healthy donors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Fungi
/
Heterocyclic Compounds, 3-Ring
Limits:
Humans
Language:
En
Journal:
J Nat Prod
Year:
2006
Document type:
Article
Affiliation country:
Germany
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA