Antibiotic bisanthraquinones produced by a streptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinata.
J Nat Prod
; 69(7): 1070-3, 2006 Jul.
Article
in En
| MEDLINE
| ID: mdl-16872146
ABSTRACT
Chemical studies of a streptomycete isolated from a cyanobacterium associated with the tropical tunicate Ecteinascidia turbinata led to the bioassay-guided purification of two antibacterial bisanthraquinone metabolites and a cytotoxic artifact. The structures, including relative configurations of these octacyclic compounds, were established by spectroscopic analyses. Their potent antibacterial properties (IC(50) = 0.15-130 microM) versus methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis and cytotoxic effects against HCT-116 cells are presented.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptomycetaceae
/
Anthraquinones
/
Cyanobacteria
/
Anti-Bacterial Agents
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Nat Prod
Year:
2006
Document type:
Article
Affiliation country:
United States