Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies.

Greinacher, Andreas; Gopinadhan, Manesh; Günther, Jens-Uwe; Omer-Adam, Mahmoud A; Strobel, Ulrike; Warkentin, Theodore E; Papastavrou, Georg; Weitschies, Werner; Helm, Christiane A

Greinacher, Andreas; Gopinadhan, Manesh; Günther, Jens-Uwe; Omer-Adam, Mahmoud A; Strobel, Ulrike; Warkentin, Theodore E; Papastavrou, Georg; Weitschies, Werner; Helm, Christiane A.

Affiliation

Greinacher A; Institute for Immunology and Transfusion Medicine, Ernst-Moritz-Arndt University, Sauerbruchstrasse, 17489 Greifswald, Germany. greinach@uni-greifswald.de

Arterioscler Thromb Vasc Biol ; 26(10): 2386-93, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16873726

Subject(s)

Antibodies/immunology; Heparin/adverse effects; Platelet Factor 4/chemistry; Platelet Factor 4/immunology; Thrombocytopenia/chemically induced; Thrombocytopenia/immunology; Adsorption; Antibody Formation; Enzyme-Linked Immunosorbent Assay; Fondaparinux; Heparin/immunology; Heparin, Low-Molecular-Weight/immunology; Humans; Microscopy, Atomic Force; Photons; Polysaccharides/immunology; Spectrum Analysis/methods

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Collection: 01-internacional Database: MEDLINE Main subject: Thrombocytopenia / Platelet Factor 4 / Heparin / Antibodies Type of study: Prognostic_studies Limits: Humans Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2006 Document type: Article Affiliation country: Germany Country of publication: United States

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