Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

Sasikumar, T K; Qiang, Li; Burnett, Duane A; Greenlee, William J; Hawes, Brian E; Kowalski, Timothy J; O'Neill, Kim; Spar, Brian D; Weig, Blair

Sasikumar, T K; Qiang, Li; Burnett, Duane A; Greenlee, William J; Hawes, Brian E; Kowalski, Timothy J; O'Neill, Kim; Spar, Brian D; Weig, Blair.

Affiliation

Sasikumar TK; Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. thavalakulamgar.sasikumar@spcorp.com

Bioorg Med Chem Lett ; 16(20): 5427-31, 2006 Oct 15.

Article in En | MEDLINE | ID: mdl-16889961

Subject(s)

Anti-Obesity Agents/pharmacology; Benzimidazoles/pharmacology; Benzimidazoles/therapeutic use; Metabolic Diseases/drug therapy; Receptors, Somatostatin/antagonists & inhibitors; Animals; Anti-Obesity Agents/chemistry; Benzimidazoles/chemistry; Binding, Competitive/drug effects; Diet; Disease Models, Animal; Drug Evaluation, Preclinical; Eating/drug effects; Humans; Mice; Mice, Obese; Molecular Conformation; Obesity/drug therapy; Rats; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Receptors, Somatostatin / Anti-Obesity Agents / Metabolic Diseases Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom

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