Strain-dependent recovery of spontaneous hindlimb movement in spinal cord transected mice (CD1, C57BL/6, BALB/c).
Behav Neurosci
; 120(4): 826-34, 2006 Aug.
Article
in En
| MEDLINE
| ID: mdl-16893288
ABSTRACT
Reorganization and plasticity after spinal cord injury have been recently shown to take place in sublesional neuronal networks, but the possibility of strain-dependent changes at that level has never been explored. The authors studied the spontaneous return of hindlimb movement in low-thoracic spinal cord transected (Tx) mice from 3 commonly used strains. Without intervention, most CD1, C57BL/6, and BALB/c mice displayed some hindlimb movement recovery after Tx. Although all assessment methods unanimously reported that CD1 displayed higher recovery levels than did the C57BL/6 and BALB/c, higher scores were generally found with the Antri-Orsal-Barthe (M. Antri, D. Orsal, & J. Y. Barthe, 2002) and the Average Combined Score (P. A. Guertin, 2005a) methods. Such spontaneous recovery in low-thoracic Tx mice is likely the result of neuronal plasticity at the lumbosacral spinal cord level, suggesting that these sublesional changes are strain dependent.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord Injuries
/
Recovery of Function
/
Hindlimb
/
Mice, Inbred Strains
/
Movement
Limits:
Animals
Language:
En
Journal:
Behav Neurosci
Year:
2006
Document type:
Article
Affiliation country:
Canada