Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF.

Kim, J H; Oh, J Y; Park, B H; Lee, D E; Kim, J S; Park, H E; Roh, M S; Je, J E; Yoon, J H; Thorne, S H; Kirn, D; Hwang, T H

Kim, J H; Oh, J Y; Park, B H; Lee, D E; Kim, J S; Park, H E; Roh, M S; Je, J E; Yoon, J H; Thorne, S H; Kirn, D; Hwang, T H.

Affiliation

Kim JH; Department of Pharmacology and MRCCMT, Dong-A University Medical College, Busan 604-714, South Korea.

Mol Ther ; 14(3): 361-70, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16905462

Subject(s)

Granulocyte-Macrophage Colony-Stimulating Factor/genetics; Liver Neoplasms/therapy; Lung Neoplasms/prevention & control; Oncolytic Virotherapy; Vaccinia virus/genetics; Animals; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor/analysis; Humans; Immunotherapy/methods; Liver Neoplasms/chemically induced; Liver Neoplasms/pathology; Lung Neoplasms/secondary; Male; Mice; Mice, Inbred Strains; Nitrosoguanidines/toxicity; Poxviridae/genetics; Rabbits; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Cytotoxic/immunology; Thymidine Kinase/genetics; Tumor Cells, Cultured; Virus Replication

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Collection: 01-internacional Database: MEDLINE Main subject: Vaccinia virus / Granulocyte-Macrophage Colony-Stimulating Factor / Oncolytic Virotherapy / Liver Neoplasms / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2006 Document type: Article Affiliation country: South Korea

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