Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

van de Kerkhof, Esther G; Ungell, Anna-Lena B; Sjöberg, Asa K; de Jager, Marina H; Hilgendorf, Constanze; de Graaf, Inge A M; Groothuis, Geny M M

van de Kerkhof, Esther G; Ungell, Anna-Lena B; Sjöberg, Asa K; de Jager, Marina H; Hilgendorf, Constanze; de Graaf, Inge A M; Groothuis, Geny M M.

Affiliation

van de Kerkhof EG; Department of Pharmacokinetics & Drug Delivery, H Deusinglaan 1, Groningen, The Netherlands. e.g.van.de.kerkhof@rug.nl

Drug Metab Dispos ; 34(11): 1893-902, 2006 Nov.

Article in En | MEDLINE | ID: mdl-16914511

Subject(s)

Colon/metabolism; Intestine, Small/metabolism; Pharmaceutical Preparations/metabolism; Adenosine Triphosphate/analysis; Colon/enzymology; Cytochrome P-450 Enzyme System/metabolism; Diffusion Chambers, Culture; Humans; Intestine, Small/enzymology; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Organ Culture Techniques; Substrate Specificity; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Colon / Intestine, Small Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2006 Document type: Article Affiliation country: Netherlands Country of publication: United States

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