Intermediate filament expression in pituitary adenomas.
Virchows Arch B Cell Pathol Incl Mol Pathol
; 58(5): 341-9, 1990.
Article
in En
| MEDLINE
| ID: mdl-1692653
ABSTRACT
Seventy-five formalin-fixed and 18 alcohol-fixed pituitary adenomas were studied immunohistochemically using antibodies to keratin, vimentin, neurofilaments (NFs), glial fibrillary acidic protein, desmin, actin, S-100 protein and a variety of pituitary hormones. The pituitary adenoma cells were positive for keratin, vimentin and NFs (68 kDa and 160 kDa) and in a few instances there was co-expression of these three types of intermediate filaments (IMFs). The pattern of keratin-specific staining showed diffuse cytoplasmic or patchy paranuclear reactivity and of NF- or vimentin-specific staining showed fibrillar or patchy paranuclear reactivity. The patchy staining seemed to decorate the fibrous body. There was no correlation between the distribution of IMFs and pituitary hormones in pituitary adenomas except that melanocyte-stimulating-hormone-positive reactivity was limited to the NF-positive adenomas. The pattern of IMF staining did not depend on hormone production in adenomas.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary Neoplasms
/
Adenoma
/
Intermediate Filament Proteins
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Virchows Arch B Cell Pathol Incl Mol Pathol
Year:
1990
Document type:
Article
Affiliation country:
Japan