Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.

Holtkamp, Silke; Kreiter, Sebastian; Selmi, Abderraouf; Simon, Petra; Koslowski, Michael; Huber, Christoph; Türeci, Ozlem; Sahin, Ugur

Holtkamp, Silke; Kreiter, Sebastian; Selmi, Abderraouf; Simon, Petra; Koslowski, Michael; Huber, Christoph; Türeci, Ozlem; Sahin, Ugur.

Affiliation

Holtkamp S; Division of Experimental and Translational Oncology, Department of Internal Medicine III, Johannes Gutenberg University, Obere Zahlbacherstr. 63, 55131 Mainz, Germany.

Blood ; 108(13): 4009-17, 2006 Dec 15.

Article in En | MEDLINE | ID: mdl-16940422

Subject(s)

Antigen Presentation; Antigens, Neoplasm/biosynthesis; Dendritic Cells/metabolism; Lymphocyte Activation; RNA Stability; RNA, Neoplasm/metabolism; Animals; Antigen Presentation/genetics; Antigen Presentation/immunology; Antigens, Neoplasm/genetics; Antigens, Neoplasm/immunology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; Cancer Vaccines/genetics; Cancer Vaccines/metabolism; Cells, Cultured; Coculture Techniques; Dendritic Cells/immunology; Dendritic Cells/transplantation; Humans; Immunotherapy, Adoptive/methods; Lymphocyte Activation/genetics; Lymphocyte Activation/immunology; Male; Mice; Neoplasms/genetics; Neoplasms/immunology; Neoplasms/therapy; Poly A/genetics; Poly A/metabolism; RNA Stability/genetics; RNA Stability/immunology; RNA, Neoplasm/genetics; RNA, Neoplasm/immunology; Transfection/methods

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Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / RNA, Neoplasm / Lymphocyte Activation / Antigen Presentation / RNA Stability / Antigens, Neoplasm Type of study: Prognostic_studies Language: En Journal: Blood Year: 2006 Document type: Article Affiliation country: Germany

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