The role of P-glycoprotein in the bioactivation of raloxifene.

Chang, Jae H; Kochansky, Christopher J; Shou, Magang

Chang, Jae H; Kochansky, Christopher J; Shou, Magang.

Affiliation

Chang JH; Merck & Co., Inc., West Point, PA 19486-0004, USA. jae_chang@merck.com

Drug Metab Dispos ; 34(12): 2073-8, 2006 Dec.

Article in En | MEDLINE | ID: mdl-16959878

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Naphthalenes/metabolism; Raloxifene Hydrochloride/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors/pharmacology; Fomepizole; Glutathione/metabolism; Hepatocytes/drug effects; Hepatocytes/metabolism; Humans; Ketoconazole/pharmacology; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Pyrazoles/pharmacology; Verapamil/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: ATP Binding Cassette Transporter, Subfamily B, Member 1 / Raloxifene Hydrochloride / Naphthalenes Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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