Analytical strategies to investigate plant N-glycan profiles in the context of plant-made pharmaceuticals.
Curr Opin Struct Biol
; 16(5): 576-83, 2006 Oct.
Article
in En
| MEDLINE
| ID: mdl-16963259
ABSTRACT
Plants are attractive hosts for the production of recombinant proteins. However, their inability to process authentic human N-glycan structures imposes a major limitation on their use as expression systems for therapeutic products. Several strategies have emerged to engineer plant N-glycans into human-compatible molecules. In this context, fast and reliable analytical strategies for the identification of plant N-glycan profiles have been developed to define the N-glycosylation pathways of crops, to monitor the production of plant-made pharmaceuticals and to assess in planta remodelling strategies.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants
/
Polysaccharides
/
Pharmaceutical Preparations
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Struct Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2006
Document type:
Article
Affiliation country:
France